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Clinical Trial Shows Promising Results for Age-related Macular Degeneration


Researchers at the USC Roski Eye Institute, in collaboration with other institutions in California, have shown that a new stem cell-based retinal implant could help people with dry age-related macular degeneration.

The researchers have published the results of their phase 1/2a study in the journal Science Translational Medicine [1].

What is dry age-related macular degeneration?

Dry age-related macular degeneration is the most common form of age-related macular degeneration and is the leading cause of visual impairment in adults aged 65 and over. The condition leads to a loss of central vision, which can cause problems with reading, writing, driving, and other tasks that rely on vision. Diseases like this can rob the elderly of their independence and put them at risk of accidents, and with around 1.7 million Americans suffering from this condition, it is a significant problem for older people.

The therapy uses a layer of human retinal pigment epithelial cells housed on a thin supporting structure, which is then implanted into the retina. Four patients received the new treatment during the trial and were monitored for a year afterward to assess the long-term safety of the approach.

No adverse side effects were observed following the implant, which suggests that the therapy is tolerated well. The researchers also found evidence that the implant had integrated with the patient’s own retinal tissue, which is required in order to restore vision.

While following up on the safety of the therapy, the researchers assessed its efficacy. Of the four patients treated, one had improved visual acuity and showed significant improvement reading an eye chart, and two patients gained some visual function. It is also worth noting that none of the four patients had further progression of vision loss during the year following the therapy.


These early results show that this therapy is well tolerated and suggest that this currently unique implant approach could help people suffering from the advanced stages of dry age-related macular degeneration. The next step for this therapy will be a full phase 2 study to assess its efficacy in a larger test group.


[1] Kashani A, Lebkowski J, Rahhal F et al. (2018) A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Science Translational Medicine Vol. 10, Issue 435, eaao4097. DOI: 10.1126/scitranslmed.aao4097

About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
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