Today, we have a small update from the Cellage team. The Cellage project is aiming to use synthetic biology to create a new way to detect the presence of harmful senescent cells as current methods are less than ideal and not as accurate as we need.
We have been quiet for a while so we thought it was time for a small update about the Cellage project.
We are working with Circularis to screen for new senescent cell promoters using a unique technological platform never used before with human or senescent cells. A promoter is a region of DNA that initiates the expression of a particular gene. Promoters are located near the transcription start sites of genes, on the same strand and upstream on the DNA. In this case, we are searching for gene expression relating to cellular senescence and using p16 and CMV promoters as our positive controls.
If this is successful we will then move onto screening for synthetic promoters from a library of over 100,000 novel synthetic promoters. The objective being to identify suitable promoters so we can develop a highly accurate way to detect the presence of senescent cells that surpasses the current state of the art methods such as p16.