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Alexander Fedintsev on Cross-Linked Collagen at EARD2020

Stiffening of the extracellular matrix may cause more than just stiff arteries.

Alexander FedintsevAlexander Fedintsev

At Ending Age-Related Diseases 2020, Dr. Alexander Fedintsev of the Institute of Biology at Komi Science Center gave a talk about collagen glycation. Cross-links caused by advanced glycation end-products such as glucosepane stiffen the extracellular matrix, leading to systemic problems. Dr. Fedintsev provides evidence showing that the stiffened ECM leads to stem cell depletion, cellular senescence, and the failure of neurons to form synapses. If this glycation can be reversed, it could lead to a partial reversal of these elements of aging.

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