Month: February 2025

Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical...

Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from the University of California, San Francisco, dare to walk an unbeaten path. Junevity pursues the ambitious goal of fixing age-related transcriptional dysregulation using short interfering...

Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint health [1]. A centuries-old observation The authors start the article with a quote from the English physician John Haygarth from 1805: the nodosities [irregularities] of...

A new study suggests that people with hypertension who receive care in their preferred language are less likely to have a major cardiovascular event or die from any cause [1]. Let’s find a common language Communication between the doctor and the patient is important, and it is becoming clear how important. A new study by...

The Arc Institute, a nonprofit research organization, has published a manuscript on its creation of Evo 2, an AI foundation model that is capable of both understanding and building full genomes of organisms. A new step in understanding biology The authors of this paper, a group of professionals largely from the Arc Institute and well-known...

No other human endeavor today holds more promise than understanding and targeting aging. The molecular mechanisms that drive aging impact overall vigor, environmental stress resistance, reproductive health, and broad disease risk, and they fundamentally change what life means by radically changing our relationship to death. Intriguingly, aging mechanisms are highly evolutionarily conserved, so much so...