May 31, 2021
A study funded by the National Institutes of Health has found that excessive alcohol consumption increases the epigenetic age of non-Hispanic White women according to the GrimAge epigenetic clock. Why We Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and...
May 31, 2021
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. What is alpha-ketoglutarate? AKG is a naturally occurring endogenous intermediary metabolite and part of the Krebs cycle, which means...
May 28, 2021
In a new paper published in Nature, a group of scientists led by Peter Fedichev explores human longevity through the concept of loss of resilience, by which the researchers mean the gradual age-related expansion of time that the body needs to recover from stress, such as illness. According to the findings, this progressive loss of...
May 28, 2021
Today, we want to announce we are doing an AMA on Reddit Futurology! The Ask Me Anything thread will be open May 28 and 29 for pre-questions, and on May 30 and 31, the PEARL team will be answering questions. This is your opportunity to ask questions about the project, which aims to launch human...
May 27, 2021
New research has identified a set of long noncoding RNAs involved in inflammaging and the senescence-associated secretory phenotype (SASP) [1]. These RNAs are conserved across a range of species, including humans, and may prove a valuable avenue for controlling senescence. Age-related RNAs RNA can broadly be divided into protein-coding RNAs and noncoding RNAs, which have...
May 27, 2021
Today, OisÃn Biotechnologies, a well-known developer of senolytics, drugs that destroy harmful senescent cells, has announced that it has more than doubled its total funding through an oversubscribed round. This has taken its total funding from $4.5 million to $9.5 million. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent....
