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Month: August 2019

The Journal Club on August 27 was hosted by Dr. Oliver Medvedik and special guest Dr. Alexander Tyshkovskiy, who works at the Gladyshev at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic was the recent paper "Identification and Application of Gene Expression Signatures Associated with Lifespan Extension" published in Cell Metabolism. This study...
Glia Alzheimer's
The macrophages resident in the brain and spinal cord appear to be a key element in the progression of Alzheimer's disease, according to the results of a new mouse study. Microglial mayhem As we age, our immune cells become increasingly dysfunctional; once-helpful cells can behave in harmful ways, promoting persistent inflammation, impairing tissue regeneration, and...
In a recent study, a team of researchers has discovered that a naturally occurring protein called Lipocalin-type prostaglandin D synthase (L-PGDS) prevents, and can destroy, the protein aggregates associated with Alzheimer's disease. Surprisingly common and with critical functions L-PGDS is a common protein, second only to albumin, in the human brain. It provides several critical...
server room
Researchers have launched a new database dedicated to mapping and understanding the complexity of cellular senescence in a bid to help us fully understand this age-related phenomenon.  Introducing the CellAge database The Human Ageing Genomic Resources (HAGR) is a series of databases and tools that have been developed to aid researchers on aging and help...
gut brain axis diagram
In a recent study, a team from the Neurobiota Research Center in Korea has discovered that reducing gut dysbiosis partially alleviates the cognitive impairment associated with Alzheimer's disease. This may seem puzzling, as the gut and the brain are separate and relatively distant organs, but this research makes sense in the context of chronic inflammation....
An image of the sun rising in the morning
It is a sure sign that the tide has turned when mainstream news outlets and magazines start publishing positive articles about aging research and the prospects of rejuvenation. A refreshing change Today, I want to highlight an article in MIT Technology Review in which the author, David Adam, gives a sensible and measured overview of...