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Month: October 2018

A new study suggests that NAD+, which declines with age, may be increased via the de novo pathway. This is potentially interesting as it presents an alternative way in which to elevate NAD+ levels versus the better-known approach of using NAD+ precursors such as NR and NMN. What is NAD? Nicotinamide adenine dinucleotide (NAD) is...
Researchers at the University of Notre Dame discovered that amino acid nitration can inhibit the activation of T cells employed in immunotherapy against cancer and that suppression of reactive nitrogen species (RNS) responsible for nitration can significantly boost the effectiveness of immunotherapy [1]. Abstract Potent immunosuppressive mechanisms within the tumor microenvironment contribute to the resistance...
Yesterday, we announced the successful completion of the NAD+ Mouse Project after a great fundraiser, but it seems we are not done yet. The research team at Harvard has announced a new stretch goal for the last two days of the campaign. A new $75,000 goal is to be the final step, and to support...
Today, we have an interview with Dr. Vera Gorbunova, who talks about the current understanding of the mechanisms of longevity and genomic stability in exceptionally long-lived mammals and how this knowledge might be used to create therapies to extend healthy human lifespan. Dr. Vera Gorbunova is an endowed Professor of Biology at the University of...
Great news! The NAD+ Mouse Project has passed its second fundraising stretch goal, which means that the experiment will greatly expand its scope. The research team will now have enough funding to buy enough NMN to conduct long-term studies on its effects on health and the aging processes. The project will monitor the mice for...
In a recent open-access study, scientists at Columbia University have demonstrated that a protein known as RbAp48 crucially interacts with osteocalcin to help preserve memory. The protein, which is present in mice as well as people, declines with age, contributing to age-related memory loss [1]. Abstract Precisely deciphering the molecular mechanisms of age-related memory loss...