Thanks to the support of the Lifespan Heroes and as part of our commitment to bringing you the latest news and events relating to longevity research, we have created the Longevity Events Calendar.
Journal Club September – Microbiome Influences Brain Health
September 28 @ 12:00 am - 1:00 pm EDT
For September, Dr. Oliver Medvedik will be taking a look at a recent paper focused on the gut microbiome and how it influences brain health.
The gut microbiome is a complex bacterial ecosystem and appears to have considerable influence over the aging process. You can learn more about the microbiome by clicking on the topic box below.
The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3–4 months) or old (19–20 months) donor mice into aged recipient mice (19–20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.
The show will be aired on our Facebook channel at 12:00 Eastern on September 28th but Lifespan Heroes can join the call live for the discussion. The zoom call details can be found below and we look forward to seeing you again soon.
Boehme, M., Guzzetta, K. E., Bastiaanssen, T. F., van de Wouw, M., Moloney, G. M., Gual-Grau, A., … & Cryan, J. F. (2021). Microbiota from young mice counteracts selective age-associated behavioral deficits. Nature Aging, 1-11.