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Warburg effect: Sugar-tagging helps drug compounds to target human prostate cancer cells

Warburg effect: Sugar-tagging helps drug compounds to target human prostate cancer cells

IMAGE: Scientists of Far Eastern Federal University (FEFU), together with German and Russian colleagues, have developed a lead compound to fight chemotherapy-resistant prostate cancer. The original design comes out as scientists… view more 

Credit: Austin Voecks @leafiest, Unsplash

Scientists of Far Eastern Federal University (FEFU), together with German and Russian colleagues, have developed a lead compound to fight chemotherapy-resistant prostate cancer. The original design comes out as scientists combine biologically active molecules from the chemically modified pigment of sea urchins with glucose molecules to deliver the active drug substance inward the tumor cells. A related article recently was published in Marine Drugs.

To cure prostate cancer scientists decided to capitalize on the Warburg effect, which turns as tumor cells inclination to eat lots of “sugar”, i.e. consume glucose compounds more intensively comparing to the majority of normal cells.

Researchers took active molecules analogous to the molecules isolated from sea urchins pigment and “sewed” on a sugar tail to them using Sulfur linker to tie up. The resulted compound was introduced to the cell culture of prostate cancer sustainable to Docetaxel, a standard chemotherapeutic drug. The outcome was cancer cells died more efficiently.



The scientific breakthrough comes out as the

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Article originally posted at

www.eurekalert.org



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