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Towards Minimally Invasive Exosome Therapies for Internal Organ Regeneration

Towards Minimally Invasive Exosome Therapies for Internal Organ Regeneration
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Targeted delivery of therapeutics remains one of the thorny issues in medical development. Everyone wants a way to deliver high doses of a therapeutic to a specific location in the body without it also ending up everywhere else. The major issue is that systemic administration will send the majority of whatever is injected into the body into the liver and lungs, and that limits the dose that can be applied to any other tissue. One approach is to conduct localized injections, but these remain a good option for internal organs only in cases of serious damage. For example, researchers here report on the adaptation of keyhole surgery techniques to the delivery of exosomes to the injured heart following a heart attack, in order to spur greater regeneration.

keyhole surgeryexosomesheart attack

Scientists have explored using stem cell therapy as a way to regrow tissue after a heart attack. But introducing stem cells directly to the heart can be risky because they could trigger an immune response or grow uncontrollably, resulting in a tumor. Therefore, researchers have tried injecting exosomes – membrane-bound sacs containing proteins, lipids, and nucleic acids secreted by stem cells – into the heart, but they often


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