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TGF-beta pathway protects against uterine cancer

TGF-beta pathway protects against uterine cancer

IMAGE: This is Dr. Martin M. Matzuk. view more 

Credit: Baylor College of Medicine

Two new mouse models of uterine cancer shed light on how this disease – the most common gynecological cancer in the U.S. – happens. Led by researchers at Baylor College of Medicine, the team of scientists found that the Transforming Growth Factor beta (TGF-beta) signaling pathway in uterine cells protects against the disease by suppressing the overgrowth and transformation into cancer cells of the endometrium, the membrane lining the inside of the uterus.

The findings, which are published in two papers in the Proceedings of the National Academy of Sciences (PNAS) today, suggest potential new therapeutic strategies that could be beneficial to patients in the future.

“The TGF-beta signaling pathway regulates the development of many types of cancer, but it was not clear whether it also played a role in uterine cancer development,” said corresponding author Dr. Martin M. Matzuk, director of the Center for Drug Discovery, Stuart A. Wallace Chair, Robert L. Moody, Sr. Chair and professor of pathology & immunology at Baylor College of Medicine.

To explore the role the TGF-beta pathway plays in uterine cancer, the Matzuk lab developed two new mouse


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