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Predicting Alzheimer's Disease via Detection of Misfolded Amyloid-β in a Blood Sample

Predicting Alzheimer's Disease via Detection of Misfolded Amyloid-β in a Blood Sample

The research community is making progress towards forms of low cost testing for Alzheimer’s disease risk. At present, the well established tests are invasive or expensive. The very early stages of Alzheimer’s disease, in which symptoms are mild or absent, are characterized by increasing levels of amyloid-β in the brain. However, amyloid-β in the brain is in a state of dynamic equilibrium with amyloid-β in the bloodstream, and in principle a suitable sensitive test can use a blood sample to assess the relevant aspects of amyloid-β burden. It takes years to validate predictions of Alzheimer’s risk of course, and here researchers report on a lengthy but successful validation of one particular blood sample assay.

making progressAlzheimer’s diseaseamyloid-βin a state of dynamic equilibrium

Using a blood test, a research team has predicted the risk of Alzheimer’s disease in people who were clinically diagnosed as not having Alzheimer’s disease but who perceived themselves as cognitively impaired. The cohort included 203 individuals. Using a test called the Immuno-Infrared Sensor, they identified all 22 subjects at study entry who developed Alzheimer’s dementia, thus the clinical symptoms, within six years.

At study entry, blood samples were taken from all the participants and analyzed using the patented

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Article originally posted at

www.fightaging.org

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