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Oncogene-induced senescence pathways weave an intricate tapestry.

Oncogene-induced senescence pathways weave an intricate tapestry.

The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumorsuppressor protein p53.

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