The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumorsuppressor protein p53.
October 23, 2020
In this panel discussion from Ending Age-Related Diseases 2020, Vadim Gladyshev of Harvard Medical School chairs a panel with Steve Horvath of UCLA, Kristen Fortney of BioAge Labs, Stanislav Skakun […]
October 20, 2020
An international collective of scientists has discovered a new cellular process: telomere transfer from antigen-presenting cells to T cells that boosts the latter’s lifespan and proliferative potential . T cells, an important element of our adaptive immune […]
October 19, 2020
Researchers have successfully used the CRISPR/Cas9 gene editing tool to destroy Ewing’s sarcoma and chronic myeloid leukemia tumor cells by targeting the fusion genes responsible for these tumors . Fusion genes, a feature in many different types […]
October 16, 2020
In his presentation at Ending Age-Related Diseases 2020, LEAF board member Javier Noris discussed the Longevity Impact Fund, the reasons why biotechnology funding has been lacking, the "valley of death" that must be crossed in order to fully fund early-stage research through the clinical trial process, and new ways in which venture capital can fund...
October 16, 2020
Insilico Medicine has announced a historic deal with the Taisho Pharmaceutical Company, which is based in Japan, in a partnership to identify and develop new senolytic drugs. The companies have agreed to collaborate on AI-powered drug discovery focused on identifying […]