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Healthcare guidelines should be updated for patients with certain adrenal tumors

Eureka Alert

Global guidelines on managing the care of patients diagnosed with common types of adrenal tumours should be updated, say researchers following a study carried out by an international collaboration.

The research, a systematic review and meta-analysis published in Annals of Internal Medicine, is a collaboration between the University of Birmingham – part of Birmingham Health Partners (BHP) in the UK – and the Mayo Clinic in the US. It was supported by the National Institute for Health Research Birmingham Biomedical Research Centre.

The researchers reviewed 32 studies reporting the outcomes of more than 4,000 patients who had non-cancerous tumours that were classed as either non-functioning adrenal tumours (NFAT) or tumours causing mild autonomous cortisol excess (MACE).

Adrenal tumours are found in the adrenal glands – part of the body’s endocrine system, which releases hormones to the blood system that play a key role in how bodies process nutrients, respond to stress and regulate sexual development and function.

There are two adrenal glands, one on the top of each kidney. A major hormone released by the adrenals is cortisol, a hormone that helps to regulate blood pressure, metabolism and the body’s reaction to stress. While having severe excess cortisol levels – a condition known as


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