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Fight Aging! Newsletter, September 28th 2020

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/

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Contents

Mitochondrial Point Mutations Contribute to Female Reproductive Aging, and NAD+ Upregulation Attenuates These Consequences in Mice
https://www.fightaging.org/archives/2020/09/mitochondrial-point-mutations-contribute-to-female-reproductive-aging-and-nad-upregulation-attenuates-these-consequences-in-mice/

https://www.fightaging.org/archives/2020/09/mitochondrial-point-mutations-contribute-to-female-reproductive-aging-and-nad-upregulation-attenuates-these-consequences-in-mice/

Today’s open access paper discusses the impact of mitochondrial DNA damage on female reproductive capabilities. Mitochondria are the power plants of the cell, a herd of hundreds of organelles responsible for packaging the chemical energy store molecule ATP, used to power cellular processes. They are additionally deeply integrated into many core cellular processes. Mitochondria are the evolved descendants of ancient symbiotic bacteria: they carry their own small genome, the mitochondrial DNA, and replicate like bacteria. Unfortunately this mitochondrial DNA is more vulnerable and less proficiently repaired than the nuclear DNA in

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