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Advocating for the Reprogramming of Cells as a Path to Treat Aging

Advocating for the Reprogramming of Cells as a Path to Treat Aging

A fair number of researchers consider cellular reprogramming to be a promising path forward for the treatment of aging. Some of these think that epigenetic change is an important cause of of aging, while others see the epigenetic changes characteristic of aging as a downstream consequence of underlying processes of damage, but consider reprogramming to be a potentially useful point of intervention regardless. Reprogramming as a basis for therapy entails at least partially pushing cells towards pluripotency, in the same manner as the production of induced pluripotent stem cells, but not so far down this path that they lose their differentiated identity and ability to function. As a side-effect, the epigenetic patterns of gene expression are reset to a more youthful configuration. Mitochondrial function improves, cell function improves. This cannot repair DNA damage, and will likely also struggle with some of the other issues of aging, such as the accumulation of waste products in long-lived cells. It does, however, appear to produce benefits in animal models, in early exploratory studies.

cellular reprogrammingepigeneticunderlying processes of damageat least partially pushing cells towards pluripotencyinduced pluripotent stem cellsdifferentiatedgene expressionMitochondrialDNA damage

Multicellular life evolved from simple unicellular organisms that could replicate indefinitely, being


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