April 14, 2025
In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by Lifespan.io. Crowdfunded research bears fruit Rapamycin: Benefits, Side Effects, and ResearchRapamycin is a macrolide, a class of antibiotic and it exhibits potent antitumor...
April 08, 2025
A new study has found that the immune remodeling associated with fasting can be recapitulated by activating a subset of neurons in the hypothalamus. The findings could be important in the context of fasting mimicking, metabolic disorders, and cancer [1]. Fasting and the immune system Decades after the modern field of geroscience was born, caloric...
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of the hypothalamus, a core region of the brain, has been suggested to be a “key factor in the development of whole-body aging” [2]. Due to...
February 27, 2025
Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from the University of California, San Francisco, dare to walk an unbeaten path. Junevity pursues the ambitious goal of fixing age-related transcriptional dysregulation using short interfering...
February 03, 2025
As rejuvenation research advances from theory to practice, more therapies start making their way into the clinic. 2025 continues with both mouse experiments and human clinical trials. Interviews Cyclarity Launches Human Trial to Cure Atherosclerosis: Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human clinical trial for a drug that aims to remove...
January 21, 2025
A new paper published in Nature Aging suggests that somatic mutations cause significant remodeling of the epigenetic landscape. The findings might be relevant to future anti-aging interventions [1]. The genome and the epigenome Genomic instability and epigenetic alterations are two of the hallmarks of aging [2]. The former occurs in somatic cells due to replication...
January 08, 2025
In a new study, researchers have found that lithocholic acid, a metabolite found in the serum of calorically restricted mice, can mimic the effects of caloric restriction [1]. Restricting calories to live longer Caloric restriction without malnutrition improves healthspan and extended lifespan in multiple model organisms and has been found to have health benefits in...
December 23, 2024
Earlier this month, for the third year in a row, the famed Buck Institute for Research on Aging hosted the Longevity Summit. This two-day event was organized by Longevity Global, a community of longevity researchers, investors, and enthusiasts, and its founder Dr. Christin Glorioso. While not the biggest or the longest conference in the field,...
December 02, 2024
While the United States has just celebrated a holiday that opposes caloric restriction, researchers there and around the world continue to discover the effects of it and other interventions against aging. Let's see what's been done in November. Interviews Rozalyn Anderson Explains Caloric Restriction: At the University of Wisconsin-Madison, Dr. Rozalyn Anderson is studying one...
November 26, 2024
Today, we bring you a selection of presentations from the annual conference organized by the Gerontological Society of America. Most of our savvy readers, if asked to name the biggest gerontology conference, would probably go with the venerable ARDD in Copenhagen or the new favorite, Hevolution Foundation’s Healthspan Summit in Riyadh. Yet, both pale in...
January 08, 2025
Discover Topics About Longevity Our goal is to share evidence-based knowledge about aging and rejuvenation among the general public and cut through the misleading and confusing storm of information out there. With that in mind, we have created a range of topics covering supplements, exercise, diet, lifestyle and more for you to enjoy. These are...
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