March 28, 2024
Hevolution announced its investment of $20 million (SAR 75,000,000) as the lead investor for a $50 million (SAR 188,000,000) Series A financing extension in Aeovian Pharmaceuticals. Hevolution’s investment will advance promising therapies that target the mTORC1 biological pathway, helping find solutions to major unmet medical needs including neurological diseases and other diseases of aging. Hevolution’s...
March 28, 2024
In Aging, researchers have published negative results on the long-term use of methylene blue and mitoquinone (MitoQ), two popular antioxidants, to sustain bone health in mice. Oxidative stress and bone health Previous work has found that oxidative stress, which is commonly associated with age-related disease and damage, is related to bone diseases. Substantial amounts of...
March 27, 2024
Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1]. Drug combinations for better treatments Cellular senescence, a state in which cells cannot divide anymore but are still metabolically active and often display senescence-associated secretory...
March 26, 2024
After a total of 69 rejection-preventing gene edits, history has been made with the first-ever successful transplantation of a pig kidney into a human patient. Xenotransplantation within reach Organ transplantation has been one of modern medicine’s biggest triumphs, helping to save innumerable lives. It is also viewed as one of the pathways to life extension....
March 25, 2024
According to a paper published in Aging, a fisetin derivative that is being investigated for brain protection may also be effective in controlling glucose and ameliorating obesity. Repurposing a repurposed compound CMS121, the focus of this study, was created by modifying fisetin, a flavonol that is well known for its effects against cellular senescence. CMS121...
March 24, 2024
In Cell, researchers have published a paper outlining the different ways in which brain cells slowly mutate with aging. The genomic damage of aging Cells accumulate mutations with aging, including brain cells [1]. However, as these researchers note, most previous research into these mutations has been on neurons rather than the glia, the helper cells...
March 22, 2024
In this new interview, David Sinclair, Harvard professor and the author of “Lifespan”, explains his theory of aging, shares parts of his health routine, and reveals which directions in today’s aging research excite him. A professor and a public figure In the longevity field, when it comes to name recognition, there’s David Sinclair and all...
March 22, 2024
According to the United Nations, the proportion of people aged over 65 now outnumber children younger than 5. The enormous growth in the elderly population is posing a socioeconomic challenge to societies worldwide, and necessitates new sweeping interventions for age-associated diseases. This year we have an incredibly exciting program with global thought-leaders sharing their latest...
March 21, 2024
In an in-depth paper in Nature, researchers have explained how astrocytes, helper cells that provide crucial brain functions, epigenetically remember things in a way that encourages inflammation. Traumatized cells Long-lived immune cells, including T cells and B cells, can remember foreign pathogens [1]. This is why people can become immune to diseases after catching them...
March 21, 2024
Spring is in the air if you are in the Northern Hemisphere, and in the theme of new growth, let’s see what the Lifespan.io team has been up to recently. Happy Birthday to Lifespan.io Today, March 21st, it is our birthday, and we celebrate 10 years of supporting rejuvenation research. Lifespan.io President Keith Comito said,...
December 19, 2023
Sponsor A Combinatorial Intervention $200.00 Sponsor A Combinatorial Intervention Dropdown AbacavirAbacavir sulfateABC294640AbirateroneAbiraterone acetate - SponsoredAbscisic Acid (Dormin)ABT 702 dihydrochlorideABT-199ABT-263 (Navitoclax)-SPONSOREDABT-737ABT-751 (E7010)ABT-888 (Veliparib)AC480 (BMS-599626)Acalisib (GS-9820) Acamprosate calciumAcarbose - SponsoredAcebutolol HClAcemetacinAcesulfame PotassiumAcetaminophenAcetanilideAcetate gossypolAcetazolamideAcetohydroxamic AcidAcetylcholine ChlorideAcetylcysteineAcipimoxAcitretinAclidinium BromideAcotiamide hydrochlorideACP-196ActaritACTB-1003Actinomycin DACY-241AcyclovirAdapaleneAdapalene sodium saltAdefovir DipivoxilAdemetionineAdemetionine disulfate tosylateAdenineAdenine HClAdenine sulfateAdenosineAdenosine 5-monophosphateAdenosine 5'-monophosphate monohydrateAdenosine 5-triphosphateAdenosine-5'-diphosphateAdiphenine HClADL5859 HClAdoxAdrenalone HClAEE788 (NVP-AEE788)Afatinib (BIBW2992)Afatinib dimaleateAfuresertibAG-120AG-14361AG-1478AG-18AG-221 (Enasidenib)Agmatine sulfateAgomelatine-SPONSOREDAHU-377...
December 19, 2023
Sponsor A Custom Experiment Description Want to help Ora Biomedical push the limit on intervention space and work with us to design a combinatorial test with 3 or more interventions? Want to sponsor an entire library not currently available through our normal MMC sponsor page? Please let us know in the form below how you’d...
December 19, 2023
Sponsor A Random Intervention $100.00 Sponsor A Random Intervention Email * Username for leader-board (optional) I don't want the intervention to be included in the open access MMC database How did you hear about sponsoring the MMC? If you are human, leave this field blank. Add To Cart Δdocument.getElementById( "ak_js_3" ).setAttribute( "value", ( new Date()...
December 19, 2023
Sponsor an intervention $100.00 Sponsor An Intervention Intervention AbacavirAbacavir sulfateABC294640AbirateroneAbiraterone acetate - SponsoredAbscisic Acid (Dormin)ABT 702 dihydrochlorideABT-199ABT-263 (Navitoclax)-SPONSOREDABT-737ABT-751 (E7010)ABT-888 (Veliparib)AC480 (BMS-599626)Acalisib (GS-9820) Acamprosate calciumAcarbose - SponsoredAcebutolol HClAcemetacinAcesulfame PotassiumAcetaminophenAcetanilideAcetate gossypolAcetazolamideAcetohydroxamic AcidAcetylcholine ChlorideAcetylcysteineAcipimoxAcitretinAclidinium BromideAcotiamide hydrochlorideACP-196ActaritACTB-1003Actinomycin DACY-241AcyclovirAdapaleneAdapalene sodium saltAdefovir DipivoxilAdemetionineAdemetionine disulfate tosylateAdenineAdenine HClAdenine sulfateAdenosineAdenosine 5-monophosphateAdenosine 5'-monophosphate monohydrateAdenosine 5-triphosphateAdenosine-5'-diphosphateAdiphenine HClADL5859 HClAdoxAdrenalone HClAEE788 (NVP-AEE788)Afatinib (BIBW2992)Afatinib dimaleateAfuresertibAG-120AG-14361AG-1478AG-18AG-221 (Enasidenib)Agmatine sulfateAgomelatine-SPONSOREDAHU-377 hemicalcium saltAHU-377(Sacubitril)Alarelin...
December 18, 2023
Help Build A Healthier Future For All!Together we can end the suffering caused by age-related diseases such as cancer, heart disease, Parkinson’s, and Alzheimer’s. Donate Today Single Recurring Choose Amount $10 USD $25 USD $50 USD $100 USD $1000 USD Donate Give Per Month $10 USD/mo $25 USD/mo $50 USD/mo $100 USD/mo $1000 USD/mo Donate...
March 28, 2024
End of Year Fundraiser 2023: Celebrating a Year of Impact As we reflect on an extraordinary year, we can't help but feel immense gratitude and pride for what we've achieved together. The generous support from our community has fueled our mission for yet another year, allowing us to continue our work towards accelerating breakthroughs in...
November 23, 2023
Support The Million Molecule Challenge For Longevity A moonshot project to rapidly advance longevity intervention discovery Researchers including Mitchell Lee and Matt Kaeberlein have launched the Million Molecule Challenge with Ora Biomedical. The project will rapidly screen a vast number of compounds with the potential to increase healthy longevity. The Million Molecule Challenge is seeking donors...
September 25, 2023
August 29, 2023
Ending Age-Related Diseases 2023 Photos Ending Age-Related Diseases 2023 marked a return to physical conferences for Lifespan.io and what a return it was! The venue at Capitale, New York City was amazing and we had so many great guests and speakers join us. Feel free to look through the photos of the event and use...
July 31, 2023
Ending Age-Related Diseases 2023 Workshops In addition to the main conference program, there will also be a selection of workshops and extra panels happening during the event. The doors open at 9am Eastern time, event starts 10am and runs until 5:30pm Eastern time. You can find the times for these below:
Oliver Medvedik, Ph.D.
Lifespan.io - Co-Founder / Vice President / Head of Research - Mindset
Aubrey de Grey, Ph.D.
LEV Foundation - Founder
Christie Sacco
Lifespan.io - Social Media Manager
Steve Hill
Lifespan.io - Editor-in-Chief / Board Director
Michael Geer
Humanity - CSO
Mattijs Vonk
Lifespan.io - Marketing
Josh Conway
Lifespan.io - Editor / Journalist
Arkadi Mazin
Lifespan.io - Science Journalist
Brian Kennedy, Ph.D.
National University Singapore - Professor of Biochemistry and Physiology
Natasha Vita-More, Ph.D.
Digital University - Longevity and Evolution Expert
Steve Horvath, Ph.D.
Altos Labs - Principal Investigator San Diego Institute of Science
Vadim Gladyshev, Ph.D.
Harvard Medical School - Professor, Medicine, Harvard Medical School
Hanadie Yousef, Ph.D.
Juvena Therapeutics - CEO
Kelsey Moody, Ph.D.
Ichor Life Sciences - CEO
Michael Lustgarten, Ph.D.
Tufts University - Nutrition, Exercise Physiology, and Sarcopenia (NEPS) Team
Maria Entraigues Abramson
SENS Research Foundation
Pat Graziosi
Lifespan.io - Life Noggin
Stephanie Dainow
Lifespan.io - Executive Director
Ryan O’Shea
Lifespan.io - Lifespan News
Nathan Cheng
On Deck Longevity Biotech - Program Director
Maria Isabella
Lifespan.io - Science Journalist
Jake Mabey
Lifespan.io - Marketing
Stephen Christopher Rose
Lifespan.io - Science Journalist
Eric Morgen, M.D.
BioAge Labs - COO and Co-founder
Dylan Livingston
Alliance for Longevity Initiatives - Founder and President
Todd White
VitaDAO - Operations Steward
Fiona Miller
quadraScope - Managing Partner
Lisa Fabiny Kiser
SENS Research Foundation - CEO
Ryan McGarry
Lifespan.io - Researcher - Mindset
Matt Kaeberlein, Ph.D.
University of Washington - Professor of Laboratory Medicine and Pathology
Nir Barzilai, M.D.
Albert Einstein College of Medicine - Department of Endocrinology Medicine and the Department of Genetics
Karl Pfleger
Aging Biotech - Founder
Robert Grisham
Lifespan.io - Life Noggin
Pranav Lakherwal
Lifespan.io - Chief of Staff
Emmett Short
Lifespan.io - Lifespan News
James Hale
Lifespan.io - Partnerships Lead
Hans Keirstead, Ph.D.
Immunis Inc. - Chairman of the Board
Chauncey St. John
Angel Protocol - Founder
Jelani Clark, Ph.D.
Desci World - Core Leadership
Omar Elnagger
Weavechain - Co-Founder & CEO
Namir Khaliq
Protostellar Media - Head of creative operations
Ben Armstrong
BitBoy Crypto - Founder
Patrick Joyce, M.D.
ResearchHub - Co-Founder
Kennedy Schaal
Rejuve Bio - CEO
Anna Drangowska-Way, Ph.D.
Lifespan.io - Science Writer
Laura Minquini
AthenaDAO - Founder
Morten Scheibye-Knudsen, Ph.D.
University of Copenhagen - Group Leader
Wojciech Sierocki, M.D.
Data Lake - Co-Founder & CEO
Brian Magierski
21 Impact Labs - Founder
Joanna Bensz
Longevity Center - CEO and Founder
Michael Ringel, Ph.D.
Boston Consulting Group - Managing Director & Senior Partner
Kenneth Bogner
Montana Senate - State Senator
Eleanor Davies
VitaDAO - Longevity Dealflow
Susan Monarez, Ph.D.
ARPA-H - Deputy Director
Mahdi Moqri, Ph.D.
Stanford University - PROFESSIONAL-NX, GENETICS
J. Robertson
Próspera - VP of Development
J. Scotch McClure
Maxwell Biosciences - CEO
Maximilian Unfried, Ph.D.
National University Singapore - Researcher
Arunun Skandarajah, Ph.D.
ARPA-H - White House Presidential Innovation Fellow
Niklas Anzinger
Infinita - General Partner
Ryan Rossner, Ph.D.
Mini circle Gene Therapy Clinic - Researcher
Walter Patterson
Mini circle Gene Therapy Clinic - Co-Founder and Chief Scientific Officer
Robin Mansukhani
Deciduous Therapeutics - CEO
Deborah Duong, Ph.D.
Rejuve.AI - Chief Technology Officer
Carolina Reis Oliveira, Ph.D.
OneSkin Technology - Co-founder and CEO
Alessandra Zonari, Ph.D.
OneSkin Technology - Co-founder, CSO
Azeem Khan
Gitcoin - Head of Impact
Harry Gandhi
Lab2Market - Program Manager
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Frailty in Extended Lifespans
Whenever the topic of increasing human lifespan is discussed, the concern is sometimes raised that a longer life would mean a life spent frail and decrepit. This is sometimes known as the Tithonus error and shows a fundamental misunderstanding of the aims of rejuvenation biotechnology.
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Yamanaka Factors - Opportunities for Rejuvenation
Drs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed that cellular identity and aging could be reset with just four reprogramming factors, it causes cells to forget their functions and organs. However, exposure to reprogramming factors for just long enough can reverse the age of a cell without erasing its identity. This is the basis of partial cellular reprogramming.
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