MitoSENS Mitochondrial Repair Project

Engineering backup copies of mitochondrial genes to place in the nucleus of the cell, aiming to prevent age-related damage and restore lost mitochondrial function.

By Dr. Matthew "Oki" O'Connor

Funding Successful. This project reached its goal before October 26, 2015.

  • $46,128

    Pledged of $30,000 Goal

  • 400

    Backers

  • campaign complete

This campaign will only be funded if at least $30,000.00 is pledged by October 26, 2015.

Share this campaign

Help raise awareness for this campaign by sharing this widget. Simply paste the following HTML code most places on the web.

Embed Code

<iframe src="https://www.lifespan.io/campaigns/sens-mitochondrial-repair-project/?widget=1" width="260px" height="500px" style="border:none" /></iframe>

A big thank you to everyone for helping us hit our goal so quickly! Please check out the campaign updates tab to learn about our stretch goals for hitting $45,000 and $60,000.
————————————————————————————————————
Each cell in the body is dependent on the efficient generation of cellular energy by mitochondria to stay alive. Critical to this process are genes encoded within the mitochondrial genome. Over time however, mutations in these genes occur as a result of constant exposure to reactive oxygen species produced by oxidative phosphorylation, the mitochondrial energy generation process. Unlike genes within the nucleus, mitochondria lack an efficient system to repair damaged DNA. This leads to accumulated mutations, resulting in mitochondrial defects and an increase in oxidative stress throughout the body. Closely correlated with this is the observation that organisms which age more slowly also consistently display lower rates of mitochondrial free radical damage. Thus, reversing and/or preventing damage to mitochondrial DNA may be a key factor in slowing the aging process.

At the SENS Research Foundation, we are in the early stages of creating an innovative system to repair these mitochondrial mutations. If this project is successful we will have demonstrated, for the first time, a mechanism that can provide your cells with a modified backup copy of the entire mitochondrial genome. This genome would then reside within the protective confines of the cell’s nucleus, thereby mitigating damage to the mitochondrial genome. In fact, during the long course of evolution, this gradual transfer of genetic information into the nucleus has already occurred with the majority of mitochondrial genome, leaving behind a mere 13 protein coding genes within the mitochondria. Demonstrating the effectiveness of this technology would be a major milestone in the prevention and reversal of aging in the human body.

Edward James Olmos describes the SENS Mitochondrial Repair Plan

We are also developing a unique method for guiding the products of these nuclear encoded mitochondrial genes back into the mitochondria, where they can then properly function. Over the last decade, engineering this last step has been the major bottleneck in achieving effective results. In our novel system, the mRNA from an engineered mitochondrial gene is guided back to the mitochondrial surface, where it is then translated into a protein by the organelle’s co-translational import system (see figure below). Once imported, it is then incorporated into the correct location within the inner mitochondrial membrane.

Our precise targeting is achieved by adding a specific sequence “tag” to both ends of the mRNA. These tags then serve to guide the information containing mRNA molecule to the mitochondrial surface. Our prior research indicates that our system of tagging yields a significantly higher efficiency of import to mitochondria than any previously published research.

Visualization of engineered ATP8 expressed in mutant cellsSENS-data-slide

Successfully completing this project will mean that we have developed a groundbreaking method that will provide us with the capability to safeguard the mitochondrial genome by creating a backup copy in the nuclear genome. The overall goal will be to test this improved targeting technology so that it can be optimally refined for use in rescuing mutated mitochondrial DNA, and thus prevent and cure what may be one of the major causes of cellular aging.

In our current research, we are using cells derived from a patient suffering from a rare mitochondrial disease, that are null for the mitochondrial ATP8 gene (i.e., the ATP8 protein is completely absent). We have inserted our improved versions of the ATP8 gene, equipped with our specialized mitochondrial tagging system, into the nuclear genome. Inserting it into the nuclear genome helps to protect the gene from oxidative damage, while our tagging system will help guide the functional protein into the mitochondria where it is needed.

We need your support at this critical juncture of the MitoSENS project. The MitoSENS team has already demonstrated the rescue of cells containing mitochondrial mutations, and has recently generated highly promising preliminary data showing the rescue of the complete loss of a mitochondrial gene. Our next steps will focus on improving the effectiveness of the targeting system, so that we can repeat our success with one mitochondrial gene to all thirteen. We will then transition this work into animal models of mitochondrial dysfunction. This would be a crucial step in what may be the development of an eventual cure for aging and aging related diseases.

We have a talented team of highly trained mitochondrial biologists working on MitoSENS. Right now the rate-limiting factor is the cost of the expensive reagents that we use for these experiments. Increasing our funding with this campaign will allow us to double the pace of our research and bring results to the public that much faster. We have made preliminary progress on rescuing function with a second gene, ATP6, and your support will help us perfect our targeting of both ATP8 and ATP6. This requires more cells, more viruses, and many new synthetic gene sequences. Specifically, we will spend your generous donations on cell culture reagents, oxygen consumption measurements, virus production, quantitative reverse transcription PCR, DNA synthesis services, and publication of our results in a peer-reviewed journal.

Your support will help take us there.

Thank You.

MitoSENS_BudgetText
MitoSENS_BudgetGraph
MitoSENS_Rewards_Header
MitoSENS_Reward_ThankYou
MitoSENS_Rewards_MitoMecha
MitoSENS_Reward_Pen
MitoSENS_Reward_TShirt
MitoSENS_Reward_ShirtAndPen
MitoSENS_Reward_ToteBag
MitoSENS_Reward_BagAndShirt
MitoSENS_Reward_Book
MitoSENS_Reward_BookAndTote
MitoSENS_Reward_VideoCall
MitoSENS_Reward_AubreyAMA
MitoSENS_Reward_MeetTheTeam
MitoSENS_Reward_DinnerWithAubrey
MitoSENS_Reward_DinnerWithEJO

Posted on 08-18-2016 by Matthew O'Connor

We are excited to announce that our successful work of backing up two mitochondrial genes into the nuclear genome has been accepted for publication in the journal Nucleic Acids Research! Please see the announcent from our recent Rejuvenation Biotechnology Conference here, starting at 2h15m6s:


Posted on 05-18-2016 by Matthew O'Connor

Hi Everyone, it’s been an amazing few months. In short, we have been tremendously successful in our efforts to rescue a mutation in the mitochondrial genome!

PrintEssentially we’ve shown that we can relocate both ATP6 and ATP8 to the nucleus and target the proteins to the mitochondria. We can show that the proteins incorporate into the correct protein complex (the ATPase) and that they improve function resulting in more ATP production. Finally, we show that the rescued cells can survive and grow under conditions which require mitochondrial energy production while the mutant cells all die.

We have finished writing up our results and submitted them for review and publication. It may take a while for our results to be published (the peer review process can be lengthy) but as soon as it is I’ll post an update here so you can see the full paper.

We have also started the project that you helped us get to our stretch goal on. We have made all the combinations of MTS with ATP6 that we proposed and are now working on testing them. I’ll let you know when we know more.

Thank you so much for your support!

Oki


Posted on 10-19-2015 by Matthew O'Connor

MitoSENS_Oki_Thumbs_up_inside_CC

Hi everyone, thanks so much for your support in reaching our initial goal! I’m proud to announce that we have just received a donation from a local company in the form of a large quantity of free DNA primers. We used the donation to design a huge set of primers that we can use to make dozens more mitochondrial targeting sequences (MTSes) to test for their ability to target proteins to the mitochondria. So instead of the 3 that we’ve tested so far we could test many different ones that we suspect might be good candidates as stretch goals for this campaign.

If we reach a total of $45,000 we can test all of these MTSes on ATP6 and see if we can bring it up to full activity.

If we reach a total of $60,000 we can also test all of these targeting signals on a 3rd gene, Cytochrome B, which has long been a challenging gene for us and others in the field to make functional. If we can get this gene working, we should be able to make any gene in the system work.

In addition, we are excited to announce matching funds! Several of you have asked for this. For every dollar that you donate to the Mitochondrial Repair Project another dollar will go directly into the SENS Research Foundation general fund to support all the great research we do at SRF. Thanks to Reason at fightaging.org for helping to organize this fund to match your donations!


32 Comments

  1. Reuben Tracey Reuben Tracey

    What a great Site, and its great to see SENS the first project, here, of course I had to back it.
    This is really important project and I really hope they meet there goal.

      • John

        That analysis showed a link between using PGP to limit mitochondrial swelling in mice tissues, which is rather interesting as a topic but unhelpful long term. In addition to disputing the relevance of your source trial (which doesn’t appear to offer a duration or suggestion that the tests increase healthy lifespan of the mice in question), I’d like to point out that protection is less beneficial in the long term, because you cannot stop damage from occurring completely no matter how well you defend an organelle, and that damage will accumulate over time. The only option is to repair or replace the damaged component which is why this sort of project is rather important.

      • Antonio

        (1) Ginseng extracts aren’t natural.
        (2) Natural products aren’t better than artificial ones.
        (3) Ginseng doesn’t protect against mitochondrial DNA damage.
        (4) This research has nothing to do with hipoxia.

  2. Giancarlo Aguirre

    WoW, now I can feel I’m helping a good cause, good, if there is another promising project for increasing life expentancy and /or reverse aging, let us know, I’ll be glad to back it up :).

  3. Gennady Stolyarov II Gennady Stolyarov II

    Best wishes on the success of this important research project – another step forward in the noble and urgently necessary war against senescence and death.

  4. Prayag Patil

    Have never seen a worthier project, clear concise goals with obvious reward in terms of improving our ability to reengineer ourselves.

  5. Brett Bellmore

    A worthwhile project to engineer a future humanity, and I’ll see if I can’t contribute, but I’d also like to see something with more theraputic potential for existing old geezers such as myself. Mitochondria *evolve* within the cell dependent on a host of circumstances, and are quite capable of remaining functional indefinately if subject to the right evolutionary ‘incentives’.

    We need to engineer circumstances such that the working mitochondria will outcompete the disfunctional ones.

  6. Jim

    I mentioned this over at the http://www.fightaging.org website – how about rather than just being a kickstarter style website lifespan.io could provide fundraiser tools? Rather than just chuck in whatever dollars I could afford and then send the page for this project to my friends, hoping they donate too, I could run a half marathon or something to raise money from my friends, much like people do with cancer etc?

    There are sites out there like http://www.justgiving.com that facilitate this already, but they take a fairly hefty approach to the fees they charge. How difficult would it be to add such facilities to lifespan.io?

    Not only could this help raise more money, it is also a promotional tool.

      • Jim

        Keith, it seems like you already have most of the infrastructure ready to go. If you could just create a private page that only people with a link could view (or just not a page with hyperlinks from the rest of the website) . I can’t afford to give much to the Mitosens campaign personally, but I might be able to raise 250-500 dollars from friends & relatives for an activity.

  7. Aaron

    Can anyone contact me to give a bit more info about the tshirt that comes with the $50 donation? I have unique fit needs so I’d like to get some details to make sure it’ll work. Thanks much. Go longevity! ;-)

  8. Victor

    What an amazing idea! I have not contributed yet, but I will. One thing that I want to suggest is different rewards: I personally don’t care about T-shirts and all that merchandise, but I would love to receive an in-depth explanation of the problem with mitochondrial mutations and the suggested solution. This would be a great perk that would help me deepen my understanding and be more involved – as I really wish I could be (I don’t have much money to support but I could contribute my time and would love to know how to do it).

    • Keith Comito Keith Comito

      Hi Victor; some of the mid-level rewards like the 30 minute video call with the team would be perfect for this sort of thing. Obviously these rewards are at higher contribution levels, but they do require the researchers to set aside time, etc.

  9. Matthew O'Connor Matthew O'Connor

    Hi everyone, in addition to all the wonderful financial support we’ve received during this campaign we’ve also had a number of inquiries about volunteering. Volunteers and interns are a huge part of SRF. If you’d like to inquire about volunteer opportunities please fill out an application so we can try to find the best way for you to help. http://www.sens.org/outreach/take-action/volunteer Please be patient as we’ve seen quite an uptick in applications this past month.

    -Oki

  10. John

    Guys, I really don’t want to register on another site. Can you work out a way for me to just plop down 10 bucks via paypal or something and do nothing else?

    Maybe I’m the only one this is bothering; if that’s the case then forget it, obviously, I’ll suck it up and do it :)

    • Keith Comito Keith Comito

      At the moment the limits paypal wanted to impose on the crowdfunding transactions made it essentially impossible to use for any real scenario. You can use paypal to donate directly to LEAF if you like, however, via the donate link in the header.

  11. Eric Schulke

    Thank life for every one of you health extending donators. You are leaders, pure and simple. That’s no overstatement. Small donations, big donations, they all lead the way for more in a big way, and in more ways than one.

  12. Antonio

    Less than $900 to go :) Since there are still 28 days left, will the project scope be extended and a new funding goal set?

  13. Giancarlo Aguirre

    You have reached the goal, now I’m sure that you would be able to do more if you pass the number, you should put another project, and I’m surprise other investigations and projects about aging hasn’t appeared in the site, is it taking so long to approve? or there is no projects jet to be fund?

    • Eric Schulke

      There are more projects lined up, but we’re waiting until we have a bit more time on our hands to jump in again. It takes a ton of effort to raise this kind of money in our relatively small, but growing communities. If you or anybody wants to join in on helping to promote the next ones then let us know.

  14. John G

    Love the research potential, I will be adding my $100 worth – good luck.
    Question 1: Any way for me to decline material “goodies” ? I would love to have a low-cost ecopy of the book and would like to see all more go towards research (dont need a tshirt, bag, etc. as cool as they are :-) ).
    Question 2: Does this count towards the 2015 Challenge Grant shown on sens.org ? Or am I better donating directly through sens.org to help take advantage of that?

    • Keith Comito Keith Comito

      Hi John, here are the answers to your questions:
      1. You could definitely email SENS and make this request. We’ll pass the info along as well.
      2. All donations made after Oct 1 on Lifespan.io will also count towards the SENS matching fundraiser.

    • Keith Comito Keith Comito

      Hi Nadav, this would likely depend on the item and how SENS will be shipping. Feel free to contact them for specifics. Otherwise they would contact you after the campaign ends to figure this out. Thanks.

  15. Rick Davis

    Where can we go to follow the progress of this research? A note every week or every other week would foster a sense of participation that might boost future donations. It might be as simple as “ordered supplies” or “started x experiment”.

    • Keith Comito Keith Comito

      Hi Rick, there is an updates tab in the campaign where Dr. O’Connor can provide updates as milestones are hit. I will be in contact with him about this. Additionally you may be contacted by SENS via email, newsletter, etc.

Leave a Reply

  • Avatar
    Marcel Mayr
    $70.00
  • Avatar
    Adam Hruby
    $25.00
  • Avatar
    Tyler_Hruby
    $25.00
  • Avatar
    Vince Mahoney
    $10.00
  • Avatar
    Chris Niemeyer
    $50.00
  • Avatar
    Franco Cortese
    $10.00
  • Avatar
    Brian So
    $70.00
  • Avatar
    Vladimir Uzun
    $70.00
  • Avatar
    Toby Rane
    $10.00
  • Avatar
    Milo de Vries
    $10.00
  • Avatar
    Samuel Ulloa
    $10.00
  • Avatar
    Charles Farquhar
    $50.00
  • Avatar
    Freya Wilde
    $10.00
  • Avatar
    Daniel Smith
    $100.00
  • Avatar
    EDOUARD DEBONNEUIL
    $25.00
  • Avatar
    Raphael Nicolle
    $2,000.00
  • Avatar
    David Wilkins
    $70.00
  • Avatar
    Gregg Helt
    $1,000.00
  • Avatar
    Anonymous
    $25.00
  • Avatar
    Rico Ebetino
    $100.00
  • Avatar
    Deepak Pillai
    $50.00
  • Avatar
    Matthew O'Connor
    $50.00
  • Avatar
    Mark Penner
    $20.00
  • Avatar
    David Chambers
    $1,000.00
  • Avatar
    Eyal Gerber
    $250.00
  • Avatar
    Anders Holmgren
    $10.00
  • Avatar
    luc oeyen
    $150.00
  • Avatar
    Lech Gudalewicz
    $25.00
  • Avatar
    Enrico Bottani
    $25.00
  • Avatar
    Michael Houston
    $150.00
  • Avatar
    Christopher Myles
    $50.00
  • Avatar
    Kate McMillen
    $10.00
  • Avatar
    Steven Eastcott
    $10.00
  • Avatar
    Kevin Goldstein
    $25.00
  • Avatar
    Christian Saller
    $300.00
  • Avatar
    Bill Hees
    $50.00
  • Avatar
    Andrea Kenyon
    $25.00
  • Avatar
    Carl Gettleman
    $70.00
  • Avatar
    Michael Greve
    $50.00
  • Avatar
    Alexandru Gherguț
    $19.00
  • Avatar
    Alexandru-Gabriel Gherguț
    $39.00
  • Avatar
    Jeremy Wilkins
    $25.00
  • Avatar
    Jarel Hambenne
    $70.00
  • Avatar
    Will Ware
    $50.00
  • Avatar
    Chris Jefferis
    $20.00
  • Avatar
    David King
    $50.00
  • Avatar
    Ed Johnson
    $25.00
  • Avatar
    Ken Bolland
    $100.00
  • Avatar
    Simon Tost
    $200.00
  • Avatar
    Tyler Dauster
    $10.00
  • Avatar
    Ed Johnson
    $10.00
  • Avatar
    Christopher Jones
    $5,000.00
  • Avatar
    Gennady Stolyarov
    $125.00
  • Avatar
    Jonathan Eden
    $10.00
  • Avatar
    Milind Padki
    $10.00
  • Avatar
    Lukas Henschke
    $10.00
  • Avatar
    Jesse LaRue
    $250.00
  • Avatar
    Chong Kai Wong
    $150.00
  • Avatar
    Boguslaw Dziewierz
    $150.00
  • Avatar
    Martin Penny
    $10.00
  • Avatar
    Adam Thomison
    $10.00
  • Avatar
    Andy
    $100.00
  • Avatar
    Rhonda Green
    $50.00
  • Avatar
    Vic Jasin
    $100.00
  • Avatar
    Michael Ostrander
    $20.00
  • Avatar
    Jean-Pierre Abello
    $50.00
  • Avatar
    martin towner
    $125.00
  • Avatar
    Koo Karimi
    $11.00
  • Avatar
    Joshua Jacobs
    $25.00
  • Avatar
    Jesse McClusky
    $10.00
  • Avatar
    Nazariy Storozhuk
    $100.00
  • Avatar
    Josip Musac
    $50.00
  • Avatar
    Ty Kenny
    $30.00
  • Avatar
    Michal Nowakiewicz
    $10.00
  • Avatar
    Joanna Baranauskas
    $250.00
  • Avatar
    Amund Hov
    $70.00
  • Avatar
    Aaron Giterman
    $50.00
  • Avatar
    Mark Whelan
    $250.00
  • Avatar
    Scott Dunn
    $250.00
  • Avatar
    Jeffrey Tsao
    $25.00
  • Avatar
    Adam Herrman
    $200.00
  • Avatar
    Paolo Costabel
    $125.00
  • Avatar
    Richard A Sundvall
    $100.00
  • Avatar
    Catalin Bogdan Pepelea
    $100.00
  • Avatar
    Steven Tuttle
    $70.00
  • Avatar
    Matthew Rea
    $150.00
  • Avatar
    Lucian Ionescu
    $100.00
  • Avatar
    Matthew Horrigan
    $25.00
  • Avatar
    Nader Chehab
    $25.00
  • Avatar
    Fabio Cassanelli
    $10.00
  • Avatar
    Trent Eady
    $151.00
  • Avatar
    Ty Kenny
    $30.00
  • Avatar
    Hayley Harrison
    $250.00
  • Avatar
    Juho
    $150.00
  • Avatar
    Brian Thomas
    $50.00
  • Avatar
    Adam Hill
    $10.00
  • Avatar
    Tomislav Plesa
    $50.00
  • Avatar
    Blaine Ford
    $25.00
  • Avatar
    Ori Takemura
    $28.00
  • Avatar
    Peter Smit
    $250.00
  • Avatar
    Gatis Birkens
    $25.00
  • Avatar
    Johnny COURMONTAGNE
    $10.00
  • Avatar
    Debbie Cole
    $20.00
  • Avatar
    Tim Holmes
    $70.00
  • Avatar
    Eugene Bystrak
    $50.00
  • Avatar
    Jonno Meindert
    $25.00
  • Avatar
    Dmitry Veselov
    $25.00
  • Avatar
    Sergejs Silko
    $500.00
  • Avatar
    Rosemarie Jauch
    $25.00
  • Avatar
    Bryan Masters
    $250.00
  • Avatar
    kyle litwin
    $150.00
  • Avatar
    Bryan Masters
    $50.00
  • Avatar
    Larry OConnor
    $100.00
  • Avatar
    Daniel Johansson
    $145.00
  • Avatar
    marian szczepkowski
    $20.00
  • Avatar
    Martin Peterson
    $25.00
  • Avatar
    Jason Lockwood
    $100.00
  • Avatar
    Andrea Sbarbaro
    $10.00
  • Avatar
    Jason Zubo
    $50.00
  • Avatar
    Dick Lepre
    $50.00
  • Avatar
    Neil Richler
    $25.00
  • Avatar
    Mike Hädrich
    $100.00
  • Avatar
    Ilya Raykhel
    $25.00
  • Avatar
    Solomon Roskin
    $25.00
  • Avatar
    Deane Williams
    $25.00
  • Avatar
    Paul Pratt
    $50.00
  • Avatar
    Charles Demailly
    $150.00
  • Avatar
    Leon Apel
    $5,000.00
  • Avatar
    Andrea Shapiro
    $50.00
  • Avatar
    Philip Steele
    $20.00
  • Avatar
    Arthur Breitman
    $10.00
  • Avatar
    Dave and Alba and Alba
    $150.00
  • Avatar
    David Saum
    $50.00
  • Avatar
    Scott Lafferty
    $50.00
  • Avatar
    Anton Tokmakov
    $150.00
  • Avatar
    Ben Zealley
    $50.00
  • Avatar
    Sandra Watt
    $105.00
  • Avatar
    Myles Berdock
    $10.00
  • Avatar
    Simon Holk
    $10.00
  • Avatar
    Tyler Mayhall
    $50.00
  • Avatar
    Steven Liao
    $10.00
  • Avatar
    Gregg Eller
    $100.00
  • Avatar
    Thomas Greenaway Short
    $10.00
  • Avatar
    Anonymous
    $25.00
  • Avatar
    Ken Alexander
    $250.00
  • Avatar
    Anonymous
    $150.00
  • Avatar
    Jonathan Cole
    $50.00
  • Avatar
    Richard Herrell
    $10.00
  • Avatar
    Logan Airey
    $150.00
  • Avatar
    Wei Cui
    $50.00
  • Avatar
    Manas Joglekar
    $150.00
  • Avatar
    Vincenzo Paduano
    $45.00
  • Avatar
    Noa Eshkar
    $10.00
  • Avatar
    Daniel Ellis
    $70.00
  • Avatar
    Eric Krastel
    $10.00
  • Avatar
    Ludvig Larsson
    $25.00
  • Avatar
    Aaron Zinger
    $50.00
  • Avatar
    Karolis Lesevicius
    $25.00
  • Avatar
    Joseph Meisenhelder
    $25.00
  • Avatar
    Adam Fishbane
    $25.00
  • Avatar
    Tyler Schroer
    $25.00
  • Avatar
    Mohir (Michael) Lustig
    $10.00
  • Avatar
    aaron vollrath
    $70.00
  • Avatar
    Alex
    $25.00
  • Avatar
    Jay Tkachuk
    $100.00
  • Avatar
    Shane Heres
    $25.00
  • Avatar
    Jarkko I.
    $150.00
  • Avatar
    Carl Tasios
    $70.00
  • Avatar
    Justin Lockhart
    $25.00
  • Avatar
    Martin Prunières
    $15.00
  • Avatar
    Adam Muntner
    $50.00
  • Avatar
    Marcelo Leal
    $150.00
  • Avatar
    Michael Beasley
    $150.00
  • Avatar
    Francois-Rene Rideau
    $25.00
  • Avatar
    Justin Comito
    $100.00
  • Avatar
    Steven Ashton
    $10.00
  • Avatar
    Perry Metzger
    $25.00
  • Avatar
    Daniel Melo
    $25.00
  • Avatar
    Sarah Constantin
    $100.00
  • Avatar
    Rob Freeman
    $10.00
  • Avatar
    Mathieu Roy
    $70.00
  • Avatar
    hugh Forward
    $500.00
  • Avatar
    Noah Ewing
    $25.00
  • Avatar
    Gina Barton
    $50.00
  • Avatar
    Stefan
    $200.00
  • Avatar
    Daniel
    $150.00
  • Avatar
    John Rothe
    $10.00
  • Avatar
    Bev MacDonald
    $150.00
  • Avatar
    Lando Verardo
    $25.00
  • Avatar
    Alexander O'Neal
    $50.00
  • Avatar
    Nathan Johnson
    $25.00
  • Avatar
    Alessandro Varetto
    $70.00
  • Avatar
    Melvin Burton
    $100.00
  • Avatar
    Tammy Richard
    $25.00
  • Avatar
    Michele Gianella
    $100.00
  • Avatar
    Tim Steeman
    $75.00
  • Avatar
    Saudina Torres
    $10.00
  • Avatar
    Nathan Wailes
    $150.00
  • Avatar
    NATHAN GARDINER
    $25.00
  • Avatar
    Pedro Correa Martín-Arroyo
    $50.00
  • Avatar
    Peter Spriggs
    $25.00
  • Avatar
    Lech Gudalewicz
    $25.00
  • Avatar
    Wade Bradley
    $25.00
  • Avatar
    Deepak Ganger
    $20.00
  • Avatar
    Michael Bertrand
    $50.00
  • Avatar
    Keith Lee
    $20.00
  • Avatar
    SeaWyrm
    $300.00
  • Avatar
    jason braswell
    $125.00
  • Avatar
    Lucas Schneble
    $250.00
  • Avatar
    Aaron Davidson
    $150.00
  • Avatar
    Matt Lee
    $50.00
  • Avatar
    Dean Donovan
    $50.00
  • Avatar
    Jacob Tennis
    $30.00
  • Avatar
    Jason Perkins
    $25.00
  • Avatar
    Lorenzo Marangoni
    $70.00
  • Avatar
    Idan Casif
    $70.00
  • Avatar
    vince comito
    $50.00
  • Avatar
    Stefania Dragojlovic
    $150.00
  • Avatar
    Anonymous
    $25.00
  • Avatar
    Adrian Crisan
    $25.00
  • Avatar
    John Mainer
    $20.00
  • Avatar
    Eric Priewe
    $25.00
  • Avatar
    Hank Pellissier
    $25.00
  • Avatar
    Michael Sherman
    $125.00
  • Avatar
    Spencer Wolf
    $25.00
  • Avatar
    Judith Bongiovi
    $25.00
  • Avatar
    Jeff Walker
    $125.00
  • Avatar
    Ramana Kumar
    $50.00
  • Avatar
    Eric Williams
    $150.00
  • Avatar
    Raymond Hardy
    $70.00
  • Avatar
    Oge Nnadi
    $1,000.00
  • Avatar
    Ty Kenny
    $10.00
  • Avatar
    Piotr Pawlik
    $50.00
  • Avatar
    Guy Bryant
    $25.00
  • Avatar
    Earl Hollembaek
    $20.00
  • Avatar
    Nick Dragojlovic
    $25.00
  • Avatar
    Sadi Khan
    $25.00
  • Avatar
    Shawn Wretham
    $20.00
  • Avatar
    Walter Tseng
    $20.00
  • Avatar
    Luca Bonaldo
    $25.00
  • Avatar
    Burly Cain
    $50.00
  • Avatar
    Daniel Sacilotto
    $10.00
  • Avatar
    Roy Mitsuoka
    $125.00
  • Avatar
    Anatoly Belikov
    $10.00
  • Avatar
    Franklin Brosenne
    $20.00
  • Avatar
    Anonymous
    $10.00
  • Avatar
    Anonymous
    $25.00
  • Avatar
    Jimmy Janow
    $50.00
  • Avatar
    wiremu hemi ruatara
    $20.00
  • Avatar
    Austin Parish
    $50.00
  • Avatar
    Sean Robertson
    $20.00
  • Avatar
    Ruben Guazzelli
    $25.00
  • Avatar
    John Mitchell
    $25.00
  • Avatar
    Adam Bazinet
    $10.00
  • Avatar
    Billy Martin
    $20.00
  • Avatar
    linette newburn
    $20.00
  • Avatar
    Kathleen Powers
    $10.00
  • Avatar
    Sherri Wretham
    $60.00
  • Avatar
    Sherri Wretham
    $20.00
  • Avatar
    Sherri Wretham
    $20.00
  • Avatar
    Jason Adair
    $25.00
  • Avatar
    Sven Bulterijs
    $10.00
  • Avatar
    Frank Dremel
    $20.00
  • Avatar
    Eugen Suman
    $65.00
  • Avatar
    Peter Neil
    $125.00
  • Avatar
    Adrian Gonzalez
    $100.00
  • Avatar
    jeffrey haas
    $20.00
  • Avatar
    Anonymous
    $25.00
  • Avatar
    Adrian Molenaar
    $10.00
  • Avatar
    clay ANDERSON
    $20.00
  • Avatar
    Amanda Stiles
    $50.00
  • Avatar
    David Landau
    $50.00
  • Avatar
    Jeremy Albuixech
    $25.00
  • Avatar
    Vivian Bohn
    $20.00
  • Avatar
    Jason LeSage
    $25.00
  • Avatar
    Brandon McIntosh
    $25.00
  • Avatar
    LARRY ABRAMS
    $125.00
  • Avatar
    marius raducan
    $10.00
  • Avatar
    Myles Berdock
    $11.00
  • Avatar
    Nicholas Juntilla
    $50.00
  • Avatar
    Grant Simmons
    $25.00
  • Avatar
    Rodney Skilton
    $20.00
  • Avatar
    michael brown
    $20.00
  • Avatar
    Carl White
    $50.00
  • Avatar
    Darrin
    $20.00
  • Avatar
    douglas marsh marsh
    $10.00
  • Avatar
    Matthew O'Connor
    $20.00
  • Avatar
    Mary Beth M
    $20.00
  • Avatar
    Daniel Scott
    $20.00
  • Avatar
    Edward Lemon
    $50.00
  • Avatar
    Jeff Pizanti
    $20.00
  • Avatar
    Anonymous
    $20.00
  • Avatar
    David Chambers
    $100.00
  • Avatar
    Grego
    $20.00
  • Avatar
    Lee Wegenast
    $20.00
  • Avatar
    Norbert Harjadi
    $20.00
  • Avatar
    Brandyn Webb
    $10.00
  • Avatar
    Terry Cole
    $20.00
  • Avatar
    Louis Burke
    $25.00
  • Avatar
    Donald Alligood
    $20.00
  • Avatar
    Mark Penner
    $20.00
  • Avatar
    Nick Shapiro
    $20.00
  • Avatar
    Jet Lee
    $50.00
  • Avatar
    Leroy Arellano
    $100.00
  • Avatar
    Jonathan West
    $10.00
  • Avatar
    Eric Schulke
    $50.00
  • Avatar
    David Stephens
    $150.00
  • Avatar
    Charles Esterbrook
    $100.00
  • Avatar
    Maria Konovalenko
    $100.00
  • Avatar
    Francisco Javier Quero Lombardero
    $10.00
  • Avatar
    Alain Domissy
    $50.00
  • Avatar
    Michael Bergerson
    $250.00
  • Avatar
    Nathan Murfey
    $25.00
  • Avatar
    Dean Smart
    $25.00
  • Avatar
    Lars Claussen
    $125.00
  • Avatar
    Sebastian Hagen
    $499.00
  • Avatar
    Veronica Gaglione
    $50.00
  • Avatar
    Curry Taylor
    $250.00
  • Avatar
    Arsen Zahray
    $150.00
  • Avatar
    Cryonica Lamm
    $50.00
  • Avatar
    Benjamin Van Eerden
    $30.00
  • Avatar
    Raymond Gough
    $10.00
  • Avatar
    Dustin D. Trammell
    $150.00
  • Avatar
    Brandon Reinhart
    $5,000.00
  • Avatar
    Mike Williams
    $50.00
  • Avatar
    Cameron Bloomer
    $70.00
  • Avatar
    Rick Davis
    $50.00
  • Avatar
    Darrell Weaver
    $25.00
  • Avatar
    Bence Kodaj
    $70.00
  • Avatar
    Florent Berthet
    $10.00
  • Avatar
    Audrey Quach
    $50.00
  • Avatar
    Jeremy Schlatter
    $200.00
  • Avatar
    Aaron Dallin
    $50.00
  • Avatar
    Thomas Murtagh
    $10.00
  • Avatar
    Sagan Bolliger
    $25.00
  • Avatar
    Nathan Lefler
    $25.00
  • Avatar
    Daniel Lemire
    $10.00
  • Avatar
    Dean Pomerleau
    $10.00
  • Avatar
    Prayag Patil
    $1,000.00
  • Avatar
    James Grugan
    $10.00
  • Avatar
    Kurren Nischal
    $50.00
  • Avatar
    Ryan Berkani
    $14.00
  • Avatar
    Jarrad Hope
    $500.00
  • Avatar
    Anders Grönnevik
    $10.00
  • Avatar
    Benjamin Short
    $150.00
  • Avatar
    Tom Sanders
    $50.00
  • Avatar
    abraham jaleel
    $25.00
  • Avatar
    Gennady Stolyarov
    $100.00
  • Avatar
    André Heinonen
    $25.00
  • Avatar
    Nell Watson
    $10.00
  • Avatar
    Paul Spiegel
    $50.00
  • Avatar
    Zoltan Istavn
    $10.00
  • Avatar
    Robert McBrayer
    $50.00
  • Avatar
    Morten Weinreich
    $10.00
  • Avatar
    Gianluca Tabbita Bonifazi
    $25.00
  • Avatar
    Michael Marye
    $150.00
  • Avatar
    Walter Crompton
    $25.00
  • Avatar
    Giancarlo Aguirre
    $10.00
  • Avatar
    Gianluca Tabbita Bonifazi
    $10.00
  • Avatar
    Marcel
    $25.00
  • Avatar
    Corbin
    $25.00
  • Avatar
    Horia Dumitru
    $10.00
  • Avatar
    William DeVore
    $50.00
  • Avatar
    Richard Heinz
    $10.00
  • Avatar
    Jay Lewis
    $50.00
  • Avatar
    Stephan Bardubitzki
    $100.00
  • Avatar
    Jan Wong
    $50.00
  • Avatar
    George Munteanu
    $10.00
  • Avatar
    Scott Niznik
    $50.00
  • Avatar
    Guillaume Galdrat
    $25.00
  • Avatar
    Rasmus Henriksen
    $50.00
  • Avatar
    Michael Greve
    $150.00
  • Avatar
    Reuben Tracey
    $25.00
  • Avatar
    Sam Holmes
    $70.00
  • Avatar
    Bruce Burke
    $250.00
  • Avatar
    Kevin Hink
    $25.00
  • Avatar
    Nico
    $250.00
  • Avatar
    Mykhailo Korbakov
    $100.00
  • Avatar
    Grant Takara
    $150.00
  • Avatar
    Omer Yousuf
    $10.00
  • Avatar
    Otto Valtakoski
    $10.00
  • Avatar
    Nicolai Kilian
    $11.00
  • Avatar
    Anat Paskin-Cherniavsky
    $70.00
  • Avatar
    Chris McAulay
    $10.00
  • Avatar
    Greg D'Agostino
    $100.00
  • Avatar
    Brian & Sabine Atkins
    $150.00
  • Avatar
    Zackerie Galhardo
    $10.00
  • Avatar
    oliver medvedik
    $10.00
  • Avatar
    Richard Fontanesi
    $150.00
  • Avatar
    Christer Holmberg
    $50.00
  • Avatar
    James joyce
    $10.00
  • Avatar
    Hunter Secrest
    $50.00
  • Avatar
    peter svensson
    $125.00
  • Avatar
    Jessica Sacco
    $50.00
  • Avatar
    Reason .
    $250.00
  • Avatar
    Christie Sacco
    $10.00
  • Avatar
    Bobby Andishmand
    $10.00
  • Avatar
    Matthew Sacco
    $25.00
  • Avatar
    Karen Comito
    $50.00

This Campaign has ended. No more pledges can be made.

  • 78 Backers

    WEBSITE THANK YOU PAGE — Your name listed on a special thank you page on our site; thanks for joining the cause! All higher donations will include this reward.

    Estimated delivery :
    Shortly after campaign completion
  • 40 Backers

    MITOMECH FOR PLAYERS OF MECHA GALAXY — A Promotional “Mito Mech” for players of the game Mecha Galaxy: www.mechagalaxy.com. Send your payment confirmation and player ID to 11527 to collect your Mito Mech, and the satisfaction of knowing you've helped a great cause.

    Estimated delivery :
    Shortly after pledge is made
  • 85 Backers

    $10 Pledge Reward + THANK YOU NOTE + SENS PEN — Personalized thank you note signed by Aubrey de Grey and a SENS Research Foundation Pen. (Shipping included from anywhere in the domestic US).

    Estimated delivery :
    2 months after campaign completes
  • 70 Backers

    $10 Pledge Reward + SENS FOUNDATION T-SHIRT — Wear your support for the cause with a stylish SENS Research Foundation T-Shirt. (Shipping included from anywhere in domestic US).

    Estimated delivery :
    2 months after campaign completes
  • 22 Backers

    $25 Pledge Reward + SENS FOUNDATION T-SHIRT — The SENS T-Shirt, Pen, and Personalized thank you note signed by Aubrey de Grey. (Shipping included from anywhere in domestic US).

    Estimated delivery :
    2 months after campaign completes
  • 28 Backers

    $25 Pledge Reward + SENS FOUNDATION TOTE BAG AND NOTEBOOK — Custom SENS Foundation Tote Bag, including SENS Notebook, Pen, and Personalized thank you note signed by Aubrey de Grey. (Shipping included from anywhere in the domestic US).

    Estimated delivery :
    2 months after campaign completes
  • 12 Backers

    $100 Pledge Reward + SENS FOUNDATION T-SHIRT — Custom SENS Foundation Tote Bag with all the items from the $100 reward level + the SENS Foundation T-Shirt. (Shipping included from anywhere in the domestic US).

    Estimated delivery :
    2 months after the campaign ends.
  • 36 Backers
    Limit of 50 — 14 remaining

    AUTOGRAPHED COPY OF "ENDING AGING" — Personalized autographed copy of Aubrey de Grey and Michael Rae's book "Ending Aging". (Shipping included from anywhere in the domestic US).

    Estimated delivery :
    3 months after the campaign ends.
  • 18 Backers
    Limit of 30 — 12 remaining

    AUTOGRAPHED COPY OF "ENDING AGING" + $125 Pledge Reward TOTE BAG — SENS Tote Bag containing all of the items from the $125 level + Personalized autographed copy of Aubrey de Grey and Michael Rae's book "Ending Aging". (Shipping included from anywhere in the domestic US).

    Estimated delivery :
    3 months after the campaign ends.
  • 3 Backers
    Limit of 10 — 7 remaining

    30 MINUTE VIDEO CALL WITH THE TEAM — 30 minute Video Call with the members of the MitoSENS team to ask questions about the progress of the program.

    Estimated delivery :
    3 months after the campaign ends.
  • 5 Backers
    All gone!

    $250 Pledge Reward + PERSONAL VIDEO AMA WITH AUBREY DE GREY — An Autographed copy of Aubrey de Grey’s book Ending Aging and your own personal 30 minute ask me anything video call with Aubrey de Grey

    Estimated delivery :
    3 months after the campaign ends.
  • Backers
    Limit of 3 — 3 remaining

    MEET THE MITOSENS TEAM — You’ll visit the SENS Research Foundation lab to observe experiments, attend a lab meeting and be treated to lunch with the team. Travel not included.

    Estimated delivery :
    Shortly after campaign completion
  • 3 Backers
    All gone!

    DINNER WITH AUBREY DE GREY AND MATTHEW O'CONNOR + SENS RESEARCH FOUNDATION TOUR — Dinner with Aubrey de Grey and Matthew O’Connor,and a Tour of the SENS Research Foundation. Travel not Included.

    Estimated delivery :
    Shortly after campaign completion
  • Backers
    Limit of 1 — 1 remaining

    DINNER WITH EDWARD JAMES OLMOS, AUBREY DE GREY, AND MATTHEW O'CONNOR — Travel is included (from anywhere in the domestic US), as well as a two-night hotel stay.

    Estimated delivery :
    Shortly after campaign completion